FATIGUE
DIABETIC FATIGUE
Fatigue can be a result of the constant fluctuations in blood glucose levels. Hypoglycemia and hyperglycemia can lead to feelings of tiredness. Tiredness was ranked 5/16 most common symptoms by diabetics in a 2010 review. The chart to the left depicts the many factors that contribute to diabetic fatigue. Fatigue can be a barrier to regular exercise, health routines, and daily activities. Peripheral fatigue is the decline in muscle force capacity with repeated stimulation. It also occurs from reductions in hepatic or muscular glycogen stores.
AMPK
Obese individuals have higher levels of fatigue, which may be due to increased levels or inflammation. Inflammation decreases AMPK activity which also leads back to fatigue (Fritschi et. al 2010)
POLYNEUROPATHY
What is it? Polyneuropathy is the deterioration of function in neurons outside of the spinal cord and brain.
Those with diabetic polyneuropathy showed a 21% faster fatigue time in maximal strength leg movements (Allen et. al 2015).
Fatigue can be a result of the constant fluctuations in blood glucose levels. Hypoglycemia and hyperglycemia can lead to feelings of tiredness. Tiredness was ranked 5/16 most common symptoms by diabetics in a 2010 review. The chart to the left depicts the many factors that contribute to diabetic fatigue. Fatigue can be a barrier to regular exercise, health routines, and daily activities. Peripheral fatigue is the decline in muscle force capacity with repeated stimulation. It also occurs from reductions in hepatic or muscular glycogen stores.
AMPK
Obese individuals have higher levels of fatigue, which may be due to increased levels or inflammation. Inflammation decreases AMPK activity which also leads back to fatigue (Fritschi et. al 2010)
POLYNEUROPATHY
What is it? Polyneuropathy is the deterioration of function in neurons outside of the spinal cord and brain.
Those with diabetic polyneuropathy showed a 21% faster fatigue time in maximal strength leg movements (Allen et. al 2015).
Guiding Research:
Allen, M. D., Kimpinski, K., Doherty, T. J., & Rice, C. L. (2015). Decreased muscle endurance associated with diabetic neuropathy may be attributed partially to neuromuscular transmission failure. Journal of Applied Physiology, 118(8), 1014–1022. http://doi.org/10.1152/japplphysiol.00441.2014
Fritschi, C., & Quinn, L. (2010). Fatigue in Patients with Diabetes: A Review. Journal of Psychosomatic Research, 69(1), 33–41. http://doi.org/10.1016/j.jpsychores.2010.01.021
Allen, M. D., Kimpinski, K., Doherty, T. J., & Rice, C. L. (2015). Decreased muscle endurance associated with diabetic neuropathy may be attributed partially to neuromuscular transmission failure. Journal of Applied Physiology, 118(8), 1014–1022. http://doi.org/10.1152/japplphysiol.00441.2014
Fritschi, C., & Quinn, L. (2010). Fatigue in Patients with Diabetes: A Review. Journal of Psychosomatic Research, 69(1), 33–41. http://doi.org/10.1016/j.jpsychores.2010.01.021